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What is Liposomal CBD?

by | Nov 24, 2020 | Blog Posts, Featured | 0 comments

As a first-time CBD user or a familiar user, the word “liposomal” probably hasn’t made its way into your research before. That’s because it is a new, groundbreaking delivery method that is just starting to make its way into the CBD market.

The CBD industry has seen near-constant innovation over the last few years. Whether it’s a tweak in extraction methods or a new delivery system, this industry knows how to keep customers on their toes. That being said, one of the latest technologies in bioavailability to look out for is liposomal CBD.

In this article, we’ll be talking about the research done on liposomal CBD delivery, what it means for you as a first-time or familiar user, and why it might just be your new favorite way to take CBD.


What are Liposomes?

To start with a breakdown of liposomal CBD and what it is, we need to go to the very basics of this delivery method.

Liposomes aren’t exclusive to CBD. These molecular spheres were discovered in the 1960s. Since then, and upon decades of improvement, liposomes have mainly been used as a vehicle to deliver medications to the body more efficiently. 

Liposomes are essentially a microscopic transportation bubble –or vesicle– comprised of at least one lipid bilayer. Historically, drug manufacturers would fill these vesicles with their product so their medication could get into the patient’s bloodstream more efficiently to fend off cancer and other diseases rather than be lost in the digestive system or broken down in the liver. 

Since the bilayer of a liposome is made of the same material as a cell membrane, it can bypass premature breakdown in the GI tract and deliver a greater active payload per particle. Liposomal CBD works in a similar fashion. The particles of cannabidiol are enveloped in a bilayer the body can more easily absorb. This increases the CBD product’s bioavailability.

In the end, all CBD products are constructed to reach the endocannabinoid system (ECS), where homeostasis is managed. As the endocannabinoid system is the orchestra conductor of transmitters and receptors throughout the entire human body (and mammal bodies in general), finding the best delivery option is very important.


What Is Bioavailability?

Bioavailability is the extent to which an active compound can be absorbed into the body. When we talk about bioavailability in reference to CBD, the ultimate goal is to absorb it into the bloodstream as quickly and as efficiently as possible.

Inhalable CBD has the highest bioavailability since the plant compounds can travel directly from the lungs into the bloodstream. But oral consumption can greatly reduce the amount of CBD your body absorbs. Why?

Once you swallow a CBD product, it must make its way through the digestive system and into the bloodstream. But since CBD molecules are hydrophobic and the digestive system is a watery environment, a lot of the CBD fails to absorb properly. In fact, most CBD products only maintain a 9-13% bioavailability rate

One way to increase oral bioavailability is to let the tincture sit under your tongue for up to a minute or more. When you take CBD sublingually, it can absorb through the mucous glands and enter the bloodstream more efficiently. But still, this doesn’t absorb all of the CBD. While you may increase your CBD milligram dosage, you’re still at the risk of losing much of the CBD active properties. Liposomal CBD aims to increase bioavailability.


Is Liposomal CBD Better?

Unlike non-liposomal CBD products, liposomal CBD can withstand the harsh conditions of the digestive tract quite well. That means you can take less while enjoying more of the potentially positive potential benefits CBD has to offer. The power of a liposomal CBD lies in its structure.

Diagram of a liposome

Liposomes are both fat-soluble and water-soluble. The hydrophobic tails of a liposome bond with the CBD particle while enveloping it in a protective layer. The hydrophilic head bonds with water molecules in our digestive system thus increasing bioavailability.

Clinical studies show that liposomal CBD does indeed absorb into the body more efficiently than non-liposomal CBD. Just one hour after the ingestion of liposomal CBD, all participants showed signs of absorption into the bloodstream. Non-liposomal CBD, on the other hand, was only detected in the bloodstream of 6 out of 15 participants.

Graphic of hemp actives in the bloodstream

Liposomal CBD does offer some compelling potential benefits; however, the ideal product can vary depending on what the user hopes to gain from their CBD regimen. For example, those who are comfortable with a lower dosage of CBD may find that CBD oil works better. Or perhaps, ingesting CBD may not be the appropriate delivery method and a topical would work better.

It really comes down to preference and goals.

It should also be mentioned that one can simply take more CBD to gain a similar blood level as with liposomal CBD. For instance, a study on canine CBD use revealed that 20 mg of liposomal CBD had a similar effect as 50 mg of non-liposomal CBD. But again, everyone’s body is completely different. When it comes to liposomal CBD, less is more in comparison to non-liposomal CBD.  

Stated differently, the body really doesn’t require a huge dosage to achieve its desired effect; the challenge is effectively getting it into the bloodstream where it can go to work!


In Conclusion

Liposomal CBD is a promising new avenue for those hoping to take advantage of its highly effective bioavailability. But since non-liposomal CBD products, such as our traditional White Label tincture, can be just as effective depending on your needs – it’s up to your personal preference. If you’re a CBD veteran and you want to optimize your daily CBD ritual, this might be a great path for you to explore. But those just dipping their toes into the world of CBD might do just fine to try out a non-liposomal CBD product. 

At Peace River, our Liposomal Formulation is one of the most effective CBD products you can find. The best thing to do is to try out each product for yourself. Visit our product line of liposomal and non-liposomal CBD today.